Title of article
Total synthesis of dolastatin 10 through ruthenium-catalyzed asymmetric hydrogenations
Author/Authors
Céline Mordant، نويسنده , , Sébastien Reymond، نويسنده , , Hitoshi Tone، نويسنده , , Damien Lavergne، نويسنده , , Ridha Touati، نويسنده , , Bechir Ben Hassine، نويسنده , , Virginie Ratovelomanana-Vidal، نويسنده , , Jean-Pierre Genêt، نويسنده ,
Issue Information
هفته نامه با شماره پیاپی سال 2007
Pages
9
From page
6115
To page
6123
Abstract
A total synthesis of dolastatin 10, a potent inhibitor of microtubule assembly, which displayed remarkable antineoplastic activity, is reported. Our synthetic approach was based upon ruthenium-promoted asymmetric hydrogenation of β-keto esters derived from (S)-Boc-proline and (S)-Boc-isoleucine for the construction of the two key units: (2R,3R)-Boc-dolaproine (Dap) and (3R)-Boc-dolaisoleucine (Dil).
Journal title
Tetrahedron
Serial Year
2007
Journal title
Tetrahedron
Record number
1091069
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