Author/Authors :
Virginie Bernat، نويسنده , , Christiane André-Barrès، نويسنده , , Michel Baltas، نويسنده , , Nathalie Saffon، نويسنده , , Henri Vial، نويسنده ,
Abstract :
In the search for new antimalarial endoperoxides related to G-factors series, using a methodology based on autoxidation of a dienol sytem, unexpected cyclic ether alcohols and hydroperoxides were obtained confirming the structure of the previously postulated biradical intermediate implicated in oxygen uptake. Antimalarial activities of PMB-endoperoxides are greatly enhanced when the peroxyhemiketal function is methylated for the G3 endoperoxide.