Title of article :
Synthesis of antimalarial G-factors endoperoxides: relevant evidence of the formation of a biradical during the autoxidation step
Author/Authors :
Virginie Bernat، نويسنده , , Christiane André-Barrès، نويسنده , , Michel Baltas، نويسنده , , Nathalie Saffon، نويسنده , , Henri Vial، نويسنده ,
Issue Information :
هفته نامه با شماره پیاپی سال 2008
Pages :
9
From page :
9216
To page :
9224
Abstract :
In the search for new antimalarial endoperoxides related to G-factors series, using a methodology based on autoxidation of a dienol sytem, unexpected cyclic ether alcohols and hydroperoxides were obtained confirming the structure of the previously postulated biradical intermediate implicated in oxygen uptake. Antimalarial activities of PMB-endoperoxides are greatly enhanced when the peroxyhemiketal function is methylated for the G3 endoperoxide.
Journal title :
Tetrahedron
Serial Year :
2008
Journal title :
Tetrahedron
Record number :
1094601
Link To Document :
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