Title of article :
Synthesis and antioxidant activity of [60]fullerene–flavonoid conjugates
Author/Authors :
Roger F. Enes، نويسنده , , Andreia S.F. Farinha، نويسنده , , Augusto C. Tome، نويسنده , , José A.S. Cavaleiro، نويسنده , , Riccardo Amorati، نويسنده , , Silvia Petrucci، نويسنده , , Gian Franco Pedulli، نويسنده ,
Issue Information :
هفته نامه با شماره پیاپی سال 2009
Pages :
10
From page :
253
To page :
262
Abstract :
Chalcone, flavone, and arylideneflavanone derivatives bearing one or two 3,5-di-tert-butyl-4-hydroxyphenyl groups were synthesized from 2′,4′-dihydroxyacetophenone and 3,5-di-tert-butyl-4-hydroxybenzaldehyde. These flavonoids were converted into the corresponding malonates and then reacted with C60 to yield the title compounds. The O–H bond dissociation enthalpies (BDE) and the chain-breaking antioxidant activity of the flavonoid derivatives and the corresponding C60 conjugates were evaluated. These results are consistent with the phenolic moiety being the main responsible for the reaction with peroxyl radicals, while the C60 part of the molecule acts synergically by trapping alkyl radicals under reduced O2 partial pressure. These novel C60–flavonoid conjugates are therefore promising leads for broad-spectrum radical scavengers.
Keywords :
Flavonoids , EPR spectroscopy , Antioxidants , Radicals , Fullerenes , Phenols
Journal title :
Tetrahedron
Serial Year :
2009
Journal title :
Tetrahedron
Record number :
1094963
Link To Document :
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