Title of article :
Catalyst and base controlled site-selective sp2 and sp3 direct arylation of azine N-oxides
Author/Authors :
Derek J. Schipper، نويسنده , , Louis-Charles Campeau، نويسنده , , Keith Fagnou، نويسنده ,
Issue Information :
هفته نامه با شماره پیاپی سال 2009
Pages :
10
From page :
3155
To page :
3164
Abstract :
Site-selective direct arylation of both sp2 and sp3 sites on azine N-oxide substrates is described. The arylation reactions are carried out in either a divergent manner or a sequential manner. The sp3 arylation reaction is applied to the synthesis of the natural products, papaverine and crykonisine, and a rationale for low reactivity of electron-deficient aryl halides is provided. Mechanistic investigations point toward the intimate involvement of the base in the mechanism of these reactions.
Journal title :
Tetrahedron
Serial Year :
2009
Journal title :
Tetrahedron
Record number :
1095314
Link To Document :
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