Author/Authors :
Laurent Gavara، نويسنده , , Thomas Boisse، نويسنده , , Jean-Pierre Hénichart، نويسنده , , Adam Daïch، نويسنده , , Benoit Rigo، نويسنده , , Philippe Gautret، نويسنده ,
Abstract :
In the context of the preparation of camptothecin and luotonin A analogs, the synthesis of some key keto-precursors and their use in Friedländer condensation are described. This paper also focuses on the stability of these keto intermediates and emphasizes the major differences between indolizinones and pyrroloquinazolinones series. Noteworthy is also the report of some original structures isolated as by-products of some experiments.
