Title of article :
Coupling of 1-Alkyl-2-(bromomethyl)aziridines with Lithium Dialkylcuprates towards 1,2-Dialkylaziridines
Author/Authors :
D’hooghe، Matthias نويسنده , , Rottiers، Mario نويسنده , , Jolie، Robrecht نويسنده , , Kimpe، Norbert De نويسنده ,
Issue Information :
روزنامه با شماره پیاپی سال 2005
Abstract :
The reactivity of 1-alkyl-2-(bromomethyl)aziridines with respect to lithium dialkylcuprates (Gilman reagents) has been evaluated for the first time, pointing to the conclusion that these substrates can be applied successfully as synthetic equivalents for the aziridinylmethyl cation synthon towards, e.g. 2-ethyl-, 2-pentyl- and 2-(phenylmethyl)aziridines in good yields.
Keywords :
nucleophilic substitution , 1,2-dialkylaziridines , Organometallics , 2-(bromomethyl)aziridines
