Title of article :
Robust synthesis of enantiopure cyclohexenyl analogues of 2/3-deoxyribose sugars as carbocyclic nucleoside precursors
Author/Authors :
Manojkumar Varada، نويسنده , , Venubabu Kotikam، نويسنده , , Vaijayanti A. Kumar، نويسنده ,
Issue Information :
هفته نامه با شماره پیاپی سال 2011
Pages :
6
From page :
5744
To page :
5749
Abstract :
An expedient synthesis of 2-deoxy (10) and 3-deoxy (11) cyclohexenyl analogues of 2-deoxy and 3-deoxy-d-ribose sugar from commercially available starting materials is reported. Highly efficient enzymatic resolution of the key compound 10 is described using lipase under hydrolytic conditions. The robust methodology applied here will be useful to synthesize cyclohexenyl nucleosides, which possess potent antiviral activity and are capable of gene silencing via RNAi or antisense applications.
Keywords :
DA reaction , Carbocyclic mimics of 2-deoxy-d-ribose and 3-deoxy-d-ribose , Enzymatic resolution , CeNA
Journal title :
Tetrahedron
Serial Year :
2011
Journal title :
Tetrahedron
Record number :
1103491
Link To Document :
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