Title of article :
Self-disproportionation of enantiomers of non-racemic chiral amine derivatives through achiral chromatography
Author/Authors :
Tsuyoshi Nakamura، نويسنده , , Kaori Tateishi، نويسنده , , Shiori Tsukagoshi، نويسنده , , Saori Hashimoto، نويسنده , , Shotaro Watanabe، نويسنده , , Vadim A. Soloshonok، نويسنده , , José Luis Ace?a، نويسنده , , Osamu Kitagawa، نويسنده ,
Issue Information :
هفته نامه با شماره پیاپی سال 2012
Pages :
5
From page :
4013
To page :
4017
Abstract :
Efficient self-disproportionation of enantiomers of several non-racemic chiral amines was achieved through conversion to N-acetamides and subsequent MPLC using an achiral column. The MPLC of these non-racemic N-acetamide derivatives gave the chart having a clear boundary between two fractions. Thus, in the less polar fraction, remarkable enantiomer enrichment was observed (>99%ee), while the ee of more polar fraction was considerably reduced. The magnitude of the enantiomer enrichments and depletions strongly depended on substituent on the amino group.
Keywords :
Enantiomers , Enrichment , Self-disproportionation , Chromatography , Phenylethylamines
Journal title :
Tetrahedron
Serial Year :
2012
Journal title :
Tetrahedron
Record number :
1104487
Link To Document :
بازگشت