Title of article :
Studies toward welwitindolinones: formal syntheses of N-methylwelwitindolinone C isothiocyanate and related natural products
Author/Authors :
Tsung-hao Fu، نويسنده , , William T. McElroy، نويسنده , , Mariam Shamszad، نويسنده , , Richard W. Heidebrecht Jr.، نويسنده , , Brian Gulledge، نويسنده , , John C. Gilbert and Stephen F. Martin، نويسنده ,
Issue Information :
هفته نامه با شماره پیاپی سال 2013
Abstract :
The formal syntheses of N-methylwelwitindolinone C isothiocyanate (4) and several other welwitindolinones 5–8 were achieved by the independent synthesis of 79. The synthesis featured a Lewis acid-mediated coupling between a heteroaryl carbinol and bis-TMS enol ether, an intramolecular enolate arylation, and an unprecedented intramolecular allylic alkylation of a γ-acyloxyenone.
Keywords :
Lewis acid-mediated coupling , Welwitindolinones , Enolate arylation , Allylic Alkylation , Alkaloids
Journal title :
Tetrahedron
Journal title :
Tetrahedron
