Author/Authors :
Song Wu، نويسنده , , Xingli Zhu، نويسنده , , Wujun He، نويسنده , , Rongming Wang، نويسنده , , Xiaohua Xie، نويسنده , , Dabin Qin، نويسنده , , Linhai Jing، نويسنده , , Zeqin Chen، نويسنده ,
Abstract :
A series of bispirooxindole derivatives have been synthesized via a cascade Michael-Cyclization reaction between isothiocyanato oxindoles and methyleneindolinones with high yields (up to 98%) and excellent diastereoselectivities (up to >95:5 dr) under mild conditions. The structure and effect on the reaction of less studied 4-substituted methyleneindolinones have also been investigated.
Keywords :
cascade reaction , Michael-cyclization reaction , Bispirooxindole , Methyleneindolinone , Isothiocyanato oxindole
