Title of article :
Simplified preparation of chirally modified nickel catalyst for enantioselective hydrogenation: A step forward to industrial use Original Research Article
Author/Authors :
Tsutomu Osawa، نويسنده , , I-Yin Sandy Lee، نويسنده , , Shinji Ikeda، نويسنده , , Takayuki Kitamura، نويسنده , , Yoshihisa Inoue، نويسنده , , Victor Borovkov، نويسنده ,
Issue Information :
روزنامه با شماره پیاپی سال 2012
Pages :
5
From page :
269
To page :
273
Abstract :
A chirally modified nickel catalyst for the enantio-differentiating hydrogenation of β-ketoesters is conventionally prepared by immersing the pre-activated metallic nickel into an aqueous solution of enantiopure tartaric acid (so called “modification step”). During the pre-activation step, nickel precursor is commonly treated with hydrogen gas at elevated temperatures of up to 473 K. The X-ray photoelectron spectral examinations of chirally modified nickel catalysts obtained under the different modification conditions revealed that the chiral modification process itself plays a major role in activating the nickel surface whilst the pre-activation procedure is a less important factor. The corresponding enantio-differentiating hydrogenations of methyl acetoacetate in the liquid phase using the prepared chiral catalysts unambiguously confirmed this conclusion, providing quantitative conversions and high enantioselectivities of up to 90%.
Keywords :
Chirally modified metallic nickel , Hydrogen activation , XPS , Methyl acetoacetate , Tartaric acid , enantioselective hydrogenation
Journal title :
Applied Catalysis A:General
Serial Year :
2012
Journal title :
Applied Catalysis A:General
Record number :
1157107
Link To Document :
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