Author/Authors :
Xin ZHOU، نويسنده , , Lian YANG، نويسنده , , Guoping Yan، نويسنده , , Wei XU، نويسنده , , Chengkai ZHOU، نويسنده , , Qiao ZHANG، نويسنده , , Liang LI، نويسنده , , Fan LIU، نويسنده , , Junfang GUO، نويسنده , , Qi ZHAO، نويسنده ,
Abstract :
Gadolinium diethylenetriamine-pentaacetic bisdopamide (Gd-DTPA-2DA) was synthesized by the incorporation of dopamine to diethylenetriaminepentaacetic acid (DTPA) and further reaction with gadolinium chloride. In vitro and in vivo properties were also evaluated. Gadolinium complex Gd-DTPA-2DA possessed higher relaxation effectiveness and less cytotoxicity to HeLa cells than that of Gd-DTPA. Moreover, Gd-DTPA-2DA greatly enhanced the contrast of MR images of the brains, provided prolonged intravascular duration, and produced highly contrasted visualization of the brain.
Keywords :
gadolinium complex , Dopamine , Brain , rare earths , Magnetic resonance imaging (MRI) , Contrast agent , diethylenetriaminepentaacetic acid
