Title of article :
Synthesis of a selective alpha-2A adrenoceptor antagonist, BRL 48962, and its characterization at cloned human alpha-adrenoceptors Original Research Article
Author/Authors :
Lee J. Beeley، نويسنده , , John M. Berge، نويسنده , , Helen Chapman، نويسنده , , Paul Hieble، نويسنده , , John Kelly، نويسنده , , Diane P. Naselsky، نويسنده , , Caroline M. Rockell، نويسنده , , Paul W. Young، نويسنده ,
Abstract :
The chiral synthesis of the potent and selective alpha-2A antagonist, BRL 48962, is described. Evaluation of BRL 48962 at cloned human alpha-adrenoceptors indicates that this antagonist has a selectivity in the order of 30-fold for the alpha-2A subtype.
