Author/Authors :
J. Bonjoch، نويسنده , , F. Diaba، نويسنده , , G. Puigb?، نويسنده , , D. Solé، نويسنده , , V. Segarra، نويسنده , , L. Santamar??a، نويسنده , , J. Beleta، نويسنده , , H. Ryder، نويسنده , , J.-M. Palacios، نويسنده ,
Abstract :
The synthesis of an azaspirocyclic analogue of FR901483, phosphate , is described based on the implementation of a key 5-endo aminocyclization promoted by iodine for direct functionalization of the 1-azaspiro[4.5]decane ring at the C-3 atom. Compound has no inhibitory activity in the cell proliferation assays reported.
Keywords :
Natural products , phosphonic acid and derivatives , immunological activity , poliycyclic heterocyclic compounds
