Title of article :
Discovery of Novel Phosphonic Acid Derivatives as New Chemical Leads for Inhibitors of TNF-α production Original Research Article
Author/Authors :
Toshiaki Matsui، نويسنده , , Shinya Takahashi، نويسنده , , Naoki Matsunaga، نويسنده , , Kazunori Nakamura، نويسنده , , Nagashige Omawari، نويسنده , , Masaru Sakai، نويسنده , , Wataru Kamoshima، نويسنده , , Kouichiro Terai، نويسنده , , Hiroyuki Ohno، نويسنده , , Takaaki Obata، نويسنده , , Hisao Nakai، نويسنده , , Masaaki Toda، نويسنده ,
Issue Information :
روزنامه با شماره پیاپی سال 2002
Pages :
9
From page :
3807
To page :
3815
Abstract :
2-(Acylamino)benzylphosphonic acid 6 derived from an artificial substrate of sphingomyelinase was found to show inhibitory activity of TNF-α production. Structural optimization was started with the chemical modification of 6. The discovery of another chemical leads 7, 8, 10 and 16 for the development of structurally new inhibitors of TNF-α production is reported.
Journal title :
Bioorganic and Medicinal Chemistry
Serial Year :
2002
Journal title :
Bioorganic and Medicinal Chemistry
Record number :
1302455
Link To Document :
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