Title of article :
Photodynamic activity of water-soluble phthalocyanine zinc(II) complexes against pathogenic microorganisms Original Research Article
Author/Authors :
Vanya Mantareva، نويسنده , , Veselin Kussovski، نويسنده , , Ivan Angelov، نويسنده , , Ekaterina Borisova، نويسنده , , Latchezar Avramov، نويسنده , , Günter Schnurpfeil، نويسنده , , Dieter W?hrle، نويسنده ,
Issue Information :
روزنامه با شماره پیاپی سال 2007
Abstract :
Photodynamic activity of tetrakis-(3-methylpyridyloxy)- and tetrakis-(4-sulfophenoxy)-phthalocyanine zinc(II) toward the gram-positive Staphylococcus aureus, the gram-negative Pseudomonas aeruginosa, and the fungi Candida albicans was studied. The drug uptake dependency with an inverse behavior to the cell density was observed. The cationic photosensitizer completely inactivated S. aureus and C. albicans, and with 4 log10 P. aeruginosa. The photoinactivation at mild experimental conditions, such as drug dose of 1.5 μM and fluence of 50 mW cm−2 for 10 min irradiation time, was shown.
Keywords :
Photodynamic inactivation , Phthalocyanines , Bacteria and fungi , Light fluence
Journal title :
Bioorganic and Medicinal Chemistry
Journal title :
Bioorganic and Medicinal Chemistry