Title of article :
Synthesis, functionalization and photo-Bergman chemistry of enediyne bioconjugates Original Research Article
Author/Authors :
Paul LaBeaume، نويسنده , , Krista Wager، نويسنده , , Danielle Falcone، نويسنده , , Mei-Jane Li، نويسنده , , Vladimir Torchilin، نويسنده , , Curtis Castro، نويسنده , , Coleen Holewa، نويسنده , , Amy E. Kallmerten، نويسنده , , Graham B. Jones، نويسنده ,
Issue Information :
روزنامه با شماره پیاپی سال 2009
Abstract :
Methodology is outlined for the chemical synthesis of versatile photo-Bergman enediyne building blocks and their conjugates. Routes to both mono and bis conjugated enediyne templates are detailed together with representative examples of their bioconjugates, nanoconjugates, PEG derivatives and water soluble salts. The immunocompetence of antibody conjugates is retained, and application in the form of reagents for photodynamic therapy (PDT) advanced.
Keywords :
Nanoparticles , PDT , Photo-Bergman , enediyne , Bioconjugate , Antibody conjugate
Journal title :
Bioorganic and Medicinal Chemistry
Journal title :
Bioorganic and Medicinal Chemistry
