Author/Authors :
Zeisig، نويسنده , , Bernd B. and Cheung، نويسنده , , Ngai and Yeung، نويسنده , , Jenny and So، نويسنده , , Chi Wai Eric، نويسنده ,
Abstract :
The lack of a proper animal model has impeded understanding of the molecular mechanism of leukemia associated with the MLL-AF4 fusion. In this issue of Cancer Cell, Krivtsov et al. report a much-improved murine Mll-AF4 model and propose a molecular link with H3K79 methylation mediated by the histone methyltransferase DOT1L.