Author/Authors :
Kopp، نويسنده , , Janel L. and von Figura، نويسنده , , Guido and Mayes، نويسنده , , Erin and Liu، نويسنده , , Fen-Fen and Dubois، نويسنده , , Claire L. and Morris IV، نويسنده , , John P. and Pan، نويسنده , , Fong Cheng and Akiyama، نويسنده , , Haruhiko and Wright، نويسنده , , Christopher V.E. and Jensen، نويسنده , , Kristin and Hebrok، نويسنده , , Matthias and Sander، نويسنده , , Maike، نويسنده ,
Abstract :
Summary
are largely classified by histologic appearance, yet morphologic features do not necessarily predict cellular origin. To determine the origin of pancreatic ductal adenocarcinoma (PDA), we labeled and traced pancreatic cell populations after induction of a PDA-initiating Kras mutation. Our studies reveal that ductal and stem-like centroacinar cells are surprisingly refractory to oncogenic transformation, whereas acinar cells readily form PDA precursor lesions with ductal features. We show that formation of acinar-derived premalignant lesions depends on ectopic induction of the ductal gene Sox9. Moreover, when concomitantly expressed with oncogenic Kras, Sox9 accelerates formation of premalignant lesions. These results provide insight into the cellular origin of PDA and suggest that its precursors arise via induction of a duct-like state in acinar cells.
