New metallocene-bridged cyclodextrin dimer: A stable derivative of the antitumor drug titanocene dichloride and its potent cytotoxity against human breast cancer (MCF-7) cells

A novel cyclodextrin dimer bridged with titanocene moiety, titanocene di[mono[6-deoxy-6-(2-(thio-1,2-dicyane ethylenylthio)ethyl thio-1,2-dicyane ethylenylthio)]-β-cyclodextrin] (6), has been synthesized and characterized by IR spectroscopy, UV spectroscopy, thermogravimetry, MALDI-TOF MS spectrum, 1H and 13C NMR spectroscopy. Especially, its potent cytotoxity against Human Breast Cancer (MCF-7) has also been studied.