Author/Authors :
Desjardins، نويسنده , , Michel and Garneau، نويسنده , , Sylvie and Desgagnés، نويسنده , , Julie and Lacoste، نويسنده , , Lucille and Yang، نويسنده , , Fu and Lapointe، نويسنده , , Jacques and Chênevert، نويسنده , , Robert، نويسنده ,
Abstract :
Glutamol adenylate10was a competitive inhibitor (Ki= 3 μM) of glutamyl-tRNA synthetase fromEscherichia coli. TheN6-benzoyl adenine derivative9was also an inhibitor (Ki∼ 60 μM). Replacement of adenine by other bases (purine, cytosine, dihydrocytosine, uridine) resulted in a more than 1000-fold loss in activity, indicating the important contribution of the adenine ring to the enzyme binding.
