Synthesis of a peptidocalix[4]arene library and identification of compounds with hydrolytic activity

A 120 member library of peptidocalix[4]arenes was synthesized and screened for catalysis of the hydrolysis of p-nitrophenyl acetate. His-Ser-His-calix[4]arene was found to catalyze this reaction with v0 = 3.24 × 10−8 M/s, an increase of 1520% above background and 30% above the tripeptide (His-Ser-His) alone.