Title of article :
Matrix metalloproteinases and vascular endothelial growth factor expression in canine leukaemias
Author/Authors :
Aricٍ، نويسنده , , Arianna and Giantin، نويسنده , , Mery and Gelain، نويسنده , , Mariaelena and Riondato، نويسنده , , Fulvio and Mortarino، نويسنده , , Michele and Comazzi، نويسنده , , Stefano and Dacasto، نويسنده , , Mauro and Castagnaro، نويسنده , , Massimo and Aresu، نويسنده , , Luca، نويسنده ,
Issue Information :
فصلنامه با شماره پیاپی سال 2013
Pages :
3
From page :
260
To page :
262
Abstract :
Matrix metalloproteinases (MMPs) and vascular endothelial growth factor (VEGF) play a coordinated role during neoplastic invasion and proliferation. VEGF and MMPs expression was investigated in canine leukaemias by immunocytochemistry (MMP-9, MMP-2, VEGF-A) and quantitative RT-PCR (MMP-2, MMP-9, MT1-MMP, TIMP-1, TIMP-2, RECK, VEGF-A, VEGF-164). Blood samples were obtained from dogs with acute leukaemia (AL; n = 11) and chronic lymphocytic leukaemia (CLL; n = 12). Levels of MMP-9, TIMP-1 and VEGF-A were higher in CLL than AL and controls. Expression of TIMP-2 and MT1-MMP mRNA was significantly higher in AL than CLL. Significant positive correlations were found between MMP-9 and TIMP-1 and between MMP-9 and VEGF-A in CLL. These results suggest a potential role of MMP-9, MT1-MMP, TIMP-1, TIMP-2 and VEGF in tissue migration and angiogenesis in canine leukaemia.
Keywords :
IMPs , dog , VEGF , Leukaemia: MMP
Journal title :
The Veterinary Journal
Serial Year :
2013
Journal title :
The Veterinary Journal
Record number :
1397208
Link To Document :
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