Study on the phase behavior of cholesterol–acetone–CO2 system and recrystallization of cholesterol by antisolvent CO2

The composition of the liquid phase of cholesterol–acetone–CO2 system was determined at 308.15 and 318.15 K in the pressure range from 0.1 to 7.5 MPa. The solubility of cholesterol in the acetone–CO2 mixture decreases with increasing pressure and increases with temperature. Recrystallization of cholesterol was performed in acetone solution by using CO2 as an antisolvent. The size of the particles obtained at different conditions was examined by scanning electron microscopy (SEM).