New synthetic ways for the preparation of high-performance liquid chromatography supports

The latest developments and in particular important synthetic aspects for the preparation of modern HPLC supports are reviewed. In this context, the chemistry of inorganic supports based on silica, zirconia, titania or aluminum oxide as well as of organic supports based on poly(styrene–divinylbenzene), acrylates, methacrylates and other, more specialized polymers is covered. Special consideration is given to modern approaches such as sol–gel technology, molecular imprinting, perfusion chromatography, the preparation of monolithic separation media as well as to organic HPLC supports prepared by new polymer technologies such as ring-opening metathesis polymerization. Synthetic particularities relevant for the corresponding applications are outlined.