Title of article :
Mathematical modeling and simulation of inulinase adsorption in expanded bed column
Author/Authors :
Moraes، نويسنده , , Caroline Costa and Mazutti، نويسنده , , Marcio A. and Rodrigues، نويسنده , , Maria Isabel and Filho، نويسنده , , Francisco Maugeri and Kalil، نويسنده , , Susana Juliano، نويسنده ,
Issue Information :
روزنامه با شماره پیاپی سال 2009
Pages :
7
From page :
4395
To page :
4401
Abstract :
A mathematical model for an expanded bed column was developed to predict breakthrough curves for inulinase adsorption on Streamline SP ion-exchange adsorbent, using a crude fermentative broth with cells as the feedstock. The kinetics and mass transfer parameters were estimated using the PSO (particle swarm optimization) heuristic algorithm. The parameters were estimated for each expansion degree (ED) using three breakthrough curves at initial inulinase concentrations of 65.6 U mL−1. In sequence, the model parameters for an ED of 2.5 were validated using the breakthrough curve at an initial concentration of 114.4 U mL−1. The applicability of the validated model in process optimization was investigated, using the model as a process simulator and experimental design methodology to optimize the column and process efficiencies. The results demonstrated the usefulness of this methodology for expanded bed adsorption processes.
Keywords :
EBA optimization , Expanded bed , Mathematical Modeling , Parameter estimation , Experimental design , Inulinase
Journal title :
Journal of Chromatography A
Serial Year :
2009
Journal title :
Journal of Chromatography A
Record number :
1512045
Link To Document :
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