Title of article :
Study on structural optimum design of implantable drug delivery micro-system
Author/Authors :
Wang، نويسنده , , Xiaopeng and Chen، نويسنده , , Tianning and Yang، نويسنده , , Zhanxiao and Wang، نويسنده , , Wanjun، نويسنده ,
Issue Information :
روزنامه با شماره پیاپی سال 2007
Pages :
10
From page :
47
To page :
56
Abstract :
In this paper, design, modeling, and simulation of a new type of controlled drug delivery system based on biodegradable polymers is report. The system consists of arrays of micro-chambers for drug storage to achieve linear release. The micro-chambers were fabricated with biodegradable polymer using the UV-LIGA technology and the controlled release process is the combined results of design of the micro-chambers and the biodegradable characteristics of the polymer. This type of drug delivery system has some unique advantages in controlled long-term drug delivery, such as improved efficiency, reduced side effect, on-spot delivery, and convenient therapy. Mathematical model has been developed for two kind of biodegradable polymer micro-system respectively, and numerical simulations were conducted to analyze the biodegradation and the controlled release process. The mathematical model can be used to optimize the structural design for controlled-release system with the desired release characteristics.
Keywords :
microstructure , Biodegradable polymers , Simulation , Drug delivery micro-system , Structural optimum design
Journal title :
Simulation Modelling Practice and Theory
Serial Year :
2007
Journal title :
Simulation Modelling Practice and Theory
Record number :
1580629
Link To Document :
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