Title of article :
Chronotherapeutics and Chronotherapeutic Drug Delivery Systems
Author/Authors :
Sajan، J نويسنده , , Cinu، TA نويسنده , , Chacko، AJ نويسنده , , Litty، J نويسنده , , Jaseeda، T نويسنده ,
Issue Information :
روزنامه با شماره پیاپی 5 سال 2009
Abstract :
Chronotherapeutics refers to a treatment method in which in vivo drug availability is timed to match
rhythms of disease, in order to optimise therapeutic outcomes and minimise side effects. It is based on
the observation that there is an interdependent relationship between peak-to-trough rhythmic activity in
disease symptoms and risk factors, pharmacologic sensitivity, and pharmacokinetics of many drugs.
The specific time that patients take their medication is very important as it has significant impact on
treatment success. Optimal clinical outcome cannot be achieved if drug plasma concentrations are
constant. If symptoms of a disease display circadian variation, drug release should also vary over time.
Drug pharmacokinetics can also be time-dependent; therefore, variations both in a disease state and in
drug plasma concentration need to be taken into consideration in developing drug delivery systems
intended for the treatment of disease with adequate dose at appropriate time. Various technologies such
as time-controlled, pulsed, triggered and programmed drug delivery devices have been developed and
extensively studied in recent years for chronopharmaceutical drug delivery. These, as well as pertinent
issues, are addressed in this review.
Keywords :
Chronotherapeutics , Circadian rhythm , Chronopharmacokinetics , Chronopharmaceutics , Drug delivery systems
Journal title :
Tropical Journal of Pharmaceutical Research
Journal title :
Tropical Journal of Pharmaceutical Research