Author/Authors :
Sato، نويسنده , , Kazuyuki and Yamazoe، نويسنده , , Satoshi and Akashi، نويسنده , , Yukiko and Hamano، نويسنده , , Tetsuya and Miyamoto، نويسنده , , Arisa and Sugiyama، نويسنده , , Shuhei and Tarui، نويسنده , , Atsushi and Omote، نويسنده , , Masaaki and Kumadaki، نويسنده , , Itsumaro and Ando، نويسنده , , Akira، نويسنده ,
Abstract :
Treatment of silyl enol ethers of various carbonyl compounds with Et2Zn and fluoroalkyl halides (Rf–X) in the presence of RhCl(PPh3)3 in DME gave the corresponding α-Rf carbonyl compounds. A highly reactive alkyl-rhodium complex which was derived from RhCl(PPh3)3 and Et2Zn must be crucial in this reaction by accelerating the reaction rate and improving the yields dramatically. This reaction overcomes difficulties on the synthesis of α-Rf carbonyl compounds due to inverse polarization of Rf–X.
Keywords :
Rhodium , ?-Fluoroalkylation , ?-Position , Silyl enol ether
