Title of article :
The synthesis of unsymmetrical S1-(3′-O-thymidine-O-methanephosphonyl)-S2-p-nitrophenyl disulfides and their reactions with triphenylphosphine
Author/Authors :
Chworos، نويسنده , , Arkadiusz and Wozniak، نويسنده , , Lucyna A and Stec، نويسنده , , Wojciech J، نويسنده ,
Issue Information :
هفته نامه با شماره پیاپی سال 2000
Abstract :
The reaction of thymidine 3′-methanephosphonothioic acid with p-nitrophenylsulfenyl chloride provides S1-(3′-O-thymidine-O-methanephosphonyl)-S2-p-nitrophenyl disulfide which, in the presence of an excess of sulfenyl chloride and triphenylphosphine gives, in a stereospecific manner, thymidine 3′-(S-p-nitrophenyl methanephosphonodithioate).
Keywords :
nucleic acid analogues , stereoselectivity , derivatives , disulfides , phosphonic acids
Journal title :
Tetrahedron Letters
Journal title :
Tetrahedron Letters