Author/Authors :
Brown، نويسنده , , George R and Foubister، نويسنده , , Alan J and Roberts، نويسنده , , Craig A and Wells، نويسنده , , Stuart L and Wood، نويسنده , , Robin، نويسنده ,
Abstract :
Much higher yields were found after shorter reaction times for the meta-substituted amination of benzenes in DMPU with microwave heating in a sealed tube (180°C, 5 h), e.g. piperidine and m-fluorobenzonitrile 1 gave the m-substituted 3 in 92% yield. These modified reaction conditions also afforded a new synthesis of unsymmetrical diamines in >80% yield.
