Author/Authors :
Onishi، نويسنده , , Tomoyuki and Otake، نويسنده , , Yasuyuki and Hirose، نويسنده , , Naoko and Nakano، نويسنده , , Takashi and Torii، نويسنده , , Takayoshi and Nakazawa، نويسنده , , Masakazu and Izawa، نويسنده , , Kunisuke، نويسنده ,
Abstract :
Dihalomethylation of several N-protected amino acid esters gave N-protected α-aminoalkyl-α′-dihalomethylketones, which are useful intermediates for the synthesis of erythro β-amino-α-hydroxycarboxylic acids, in good yield. The dihalomethylketones were successfully converted to N-protected α-aminoalkyl-α′-halomethylketones by selective catalytic hydrogenation.
