Author/Authors :
Aszodi، نويسنده , , Jozsef and Fauveau، نويسنده , , Patrick and Melon-Manguer، نويسنده , , Dominique and Ehlers، نويسنده , , Eberhard and Schio، نويسنده , , Laurent، نويسنده ,
Abstract :
A new diol-carbonyl transposition reaction has been discovered in echinocandin type structures. An α-hydroxy hemiaminal moiety has been shown to undergo a pinacol-type rearrangement in the presence of trimethylsilyl iodide to afford ketone derivatives. Applied to deoxymulundocandin, this transposition led to a useful intermediate for further chemical modification.
