Title of article :
Synthesis of enantiomerically enriched Baylis–Hillman alcohols from their acetates: combination of kinetic resolution during the salt formation with (DHQD)2PHAL and following asymmetric induction during hydrolysis with NaHCO3 as a water surrogate
Author/Authors :
Kim، نويسنده , , Jae Nyoung and Lee، نويسنده , , Hong Jung and Gong، نويسنده , , Ji Hyeon، نويسنده ,
Issue Information :
هفته نامه با شماره پیاپی سال 2002
Pages :
6
From page :
9141
To page :
9146
Abstract :
Enantiomerically enriched Baylis–Hillman alcohols 2a–d (S) were prepared in 25–42% yields with optical purities of 54–92% ee by using the combined concept of kinetic resolution during the salt formation of racemic Baylis–Hillman acetates 1a–d with (DHQD)2PHAL and the asymmetric induction during the SN2′ type reaction with sodium bicarbonate as a water surrogate.
Keywords :
Baylis–Hillman alcohol , kinetic resolution , Cinchona alkaloid , water surrogate , Asymmetric induction
Journal title :
Tetrahedron Letters
Serial Year :
2002
Journal title :
Tetrahedron Letters
Record number :
1659481
Link To Document :
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