Author/Authors :
Berber، نويسنده , , Hatice and Soufyane، نويسنده , , Mustapha and Santillana-Hayat، نويسنده , , Maud and Mirand، نويسنده , , Catherine، نويسنده ,
Abstract :
Some 4-trifluoromethyl-2-aminopyrimidines analogous to trimethoprim and 5-trifluoroethyl-2,4-diaminopyrimidines analogous to pyrimethamine were prepared from enamino(trifluoromethyl)ketones and α-trifluoroacetylpropanenitriles, respectively. A novel heterocyclisation between a trifluoromethylated β-ketonitrile and guanidine was described.