Title of article
Structures and cytotoxicities of fascaplysin and related alkaloids from two marine phyla—Fascaplysinopsis sponges and Didemnum tunicates
Author/Authors
Segraves، William A. نويسنده , , Nathaniel L and Lopez، نويسنده , , Suzette and Johnson، نويسنده , , Tyler A and Said، نويسنده , , Sadri A and Fu، نويسنده , , Xiong and Schmitz، نويسنده , , Francis J and Pietraszkiewicz، نويسنده , , Halina and Valeriote، نويسنده , , Frederick A and Crews، نويسنده , , Phillip، نويسنده ,
Issue Information
هفته نامه با شماره پیاپی سال 2003
Pages
5
From page
3471
To page
3475
Abstract
The structural variations and bioactivity properties of the alkaloids in the fascaplysin (1) and the reticulatine (3) families were examined. Four organisms were analyzed consisting of two collections of the sponge Fascaplysinopsis reticulata and two collections of the tunicate Didemnum sp. Reported are the isolation of three new compounds: 3-bromofascaplysin (2), 14-bromoreticulatine (4), and 14-bromoreticulatate (6) along with reticulatate (5) previously known as a semi-synthetic product of 1. Compounds 1 and 5 showed selectivity in a cell based cytotoxicity assay.
Keywords
Didemnum , fascaplysin , Fascaplysinopsis , tunicate , alkaloid , Sponge
Journal title
Tetrahedron Letters
Serial Year
2003
Journal title
Tetrahedron Letters
Record number
1661868
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