Issue Information :
روزنامه با شماره پیاپی سال 2006
Pages :
4
From page :
68
To page :
71
Abstract :
The possibility to obtain amorphous budesonide stabilised by blending with an excipient characterised by a higher glass transition temperature, namely α-lactose, has been studied. We carried out the mixing of the two compounds at room temperature by ball-milling. The four obtained blends (containing, respectively, 10, 30, 50 and 70%w of budesonide) are X-ray amorphous and exhibit a single glass transition located between the ones of pure milled crystalline compounds. This revealed that the two amorphous phases are miscible whatever the composition and sufficiently mixed to relax as a whole. Ball-milling thus appears as a powerful tool to form amorphous molecular alloys with enhanced stability properties.
Journal title :
Acta Tropica
Serial Year :
2006
Journal title :
Acta Tropica
Record number :
1749549
Link To Document :
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