Title of article :
Suppression of tumor growth by the 3′ untranslated region of mel-18 in 3Y1 cells transformed by the E6 and E7 genes of human papillomavirus type 18
Author/Authors :
Ishiwatari، نويسنده , , Haruko and Nakanishi، نويسنده , , Kazuyoshi and Kondoh، نويسنده , , Gen and Hayasaka، نويسنده , , Naoto and Li، نويسنده , , Qin and Yamashita، نويسنده , , Atsuko and Inoue، نويسنده , , Hirokazu and Hakura، نويسنده , , Akira، نويسنده ,
Issue Information :
روزنامه با شماره پیاپی سال 1997
Pages :
9
From page :
57
To page :
65
Abstract :
By introducing a cDNA library derived from rat embryonic fibroblast cells, we isolated several morphologically flat revertants of rat 3Y1 cells transformed by the E6 and E7 genes of human papillomavirus type 18 (HPV18). From one of the revertants, we recovered a 0.2-kb cDNA, N56, that suppresses the tumor growth of the transformed 3Y1 cells irrespective of the expression of the E6 and E7 genes. The nucleotide sequence of the cDNA was shown to be identical to that of the 3′ untranslated region of a putative mammalian polycomb group gene, mel-18.
Keywords :
HPV , mel-18 , Tumor suppressor gene
Journal title :
Cancer Letters
Serial Year :
1997
Journal title :
Cancer Letters
Record number :
1798601
Link To Document :
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