Author/Authors :
Ko، نويسنده , , Josephine Mun-Yee and Cheung، نويسنده , , Michael Ho-Yin and Wong، نويسنده , , Chow-Ming and Lau، نويسنده , , Kwok-Wai and Tang، نويسنده , , Cecilia Man-Ching and Kwan، نويسنده , , Ming Wa and Lung، نويسنده , , Maria Li، نويسنده ,
Abstract :
This study investigated the frequency and importance of Ki-ras codon 12 mutations in 99 Hong Kong Chinese colorectal carcinoma specimens by allele-specific oligonucleotide hybridization. The frequency of mutations detected was 30% and the most common mutation observed resulted in aspartic acid substitutions. Previous studies showed that specific Ki-ras mutations have been significantly associated with prognosis. Ki-ras codon 12 point mutational activation in CRC was significantly associated with the differentiation status of tumors in this study. Ethnic differences in the patterns of Ki-ras codon 12 point mutations were observed.
