Author/Authors :
Park، نويسنده , , Won Sang and Oh، نويسنده , , Ro Ra and Park، نويسنده , , Jik Young and Yoo، نويسنده , , Nam-Jin and Lee، نويسنده , , Sug Hyung and Shin، نويسنده , , Min-Sun and Kim، نويسنده , , Su Young and Kim، نويسنده , , Young Sil and Lee، نويسنده , , Jong-Heun and Kim، نويسنده , , Hong Sug and An، نويسنده , , Won Gun and Lee، نويسنده , , Jung Young، نويسنده ,
Abstract :
To determine the minimal region of deletion on 21q22 in gastric cancer, we performed a high-density loss of heterozygosity (LOH) study with eight polymorphic microsatellite markers. Among the 43 tumors examined, 20 (50%) of 40 informative carcinomas showed LOH at one or more loci. The peak LOH frequency was identified at D21S1820 (34.2%) in 21q22.3. This data suggests that this locus might harbor a new tumor suppressor gene in an area <0.332 Mb in physical map distance defined by D21S1820 and D21S49. Thus, we speculate that trefoil factor family 1 (TFF1), located in this narrow region, might be the most probable candidate gene involved in gastric cancer carcinogenesis.
