Author/Authors :
Wang، نويسنده , , Qun and Lu، نويسنده , , Jiayun and Yang، نويسنده , , Cuihong and Wang، نويسنده , , Xiuqin and Cheng، نويسنده , , Yi-Lu and Hu، نويسنده , , Gengxi and Sun، نويسنده , , Yuntian and Zhang، نويسنده , , Xun and Wu، نويسنده , , Min and Liu، نويسنده , , Zhihua، نويسنده ,
Abstract :
Calcium/calmodulin-dependent serine protein kinase (CASK) showed overexpression in human esophageal carcinoma by suppression subtractive hybridization. The upregulation of CASK gene and its target gene Reelin in human esophageal carcinoma tissues versus corresponding normal tissues was revealed by reverse transcription polymerase chain reaction (RT-PCR), immunohistochemistry or Western blot. Moreover, RT-PCR results indicated that the expression patterns of CASK and Reelin in human gastric carcinoma and colon carcinoma were different with those in esophageal carcinoma. Therefore, it suggested that CASK and Reelin were associated with tumorigenesis of esophagus and they were co-upregulated in human esophageal carcinoma.
