Author/Authors :
Hamajima، نويسنده , , Nobuyuki and Matsuo، نويسنده , , Keitaro and Suzuki، نويسنده , , Takashi and Nakamura، نويسنده , , Tsuneya and Matsuura، نويسنده , , Akira and Hatooka، نويسنده , , Shunzo and Shinoda، نويسنده , , Masayuki and Kodera، نويسنده , , Yasuhiro and Yamamura، نويسنده , , Yoshitaka and Hirai، نويسنده , , Takashi and Kato، نويسنده , , Tomoyuki and Tajima، نويسنده , , Kazuo، نويسنده ,
Abstract :
A case-control study was conducted to examine the possible association between digestive tract cancers and p73 G4C14-to-A4T14 at exon 2 and p53 Arg72Pro polymorphisms in Japanese. Cases were 102 esophageal cancer patients, 144 stomach cancer patients, and 147 colorectal cancer patients, and controls were 241 non-cancer outpatients. The genotype frequencies among controls were 55.3% for p73 GG at position 4, 40.4% for GA, and 4.3% for AA, and 37.7% for p53 ArgArg, 44.4% for ArgPro, and 18.0% for ProPro. No significant differences in the genotype frequencies were observed between the controls and each case group or cases as a whole.
Keywords :
p73 dinucleotide polymorphism , p53 Arg72Pro polymorphism , Esophageal cancer risk , Stomach cancer risk , Colorectal cancer risk , Polymerase chain reaction with confronting two-pair primers
