Title of article :
ERCC6/CSB gene polymorphisms and lung cancer risk
Author/Authors :
Ma، نويسنده , , Hongxia and Hu، نويسنده , , Zhibin and Wang، نويسنده , , Haifeng and Jin، نويسنده , , Guangfu and Wang، نويسنده , , Ying and Sun، نويسنده , , Weiwei and Chen، نويسنده , , Dan and Tian، نويسنده , , Tian and Jin، نويسنده , , Li and Wei، نويسنده , , Qingyi and Lu، نويسنده , , Daru and Huang، نويسنده , , Wei and Shen، نويسنده , , Hongbing، نويسنده ,
Issue Information :
روزنامه با شماره پیاپی سال 2009
Pages :
5
From page :
172
To page :
176
Abstract :
Nucleotide excision repair (NER) enzymes are critical for the removal of bulky DNA adducts caused by environmental carcinogens such as smoking. Of them, Cockayne syndrome complementation group B (CSB), coded by ERCC6, recruits NER repair factors to the DNA damage site and plays an important role in the repair process. Genetic variants of ERCC6 may alter the regulation of DNA repair and therefore were hypothesized to be associated with altered risk of smoking-related lung cancer. To test this hypothesis, we genotyped eight tagging single nucleotide polymorphisms (tSNPs) and three potentially functional SNPs of ERCC6 in 500 incident lung cancer cases and 517 controls in a Chinese population. Single locus analyses showed that none of the single SNP alone had the significant main affect on the risk of lung cancer. However, the combined variant genotypes of the four loci with Ptrend approaching to 0.10 (rs2228526, rs4253160, rs12571445 and rs3793784) were associated with a significantly increased lung cancer risk (adjusted OR 1.35, 95% CI, 1.04–1.75 among subjects carrying three or more variant alleles), indicating that multiple loci in ERCC6 may jointly contribute to the susceptibility of lung cancer. These findings, if validated, may contribute to identify at-risk subjects in the general population for smoking-related lung cancer.
Keywords :
molecular epidemiology , single nucleotide polymorphism , lung cancer , ERCC6
Journal title :
Cancer Letters
Serial Year :
2009
Journal title :
Cancer Letters
Record number :
1813373
Link To Document :
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