Title of article :
Identification of an AKT-dependent signalling pathway that mediates tamoxifen-dependent induction of the pro-metastatic protein anterior gradient-2
Author/Authors :
Hrstka، نويسنده , , Roman and Murray، نويسنده , , Euan and Brychtova، نويسنده , , Veronika and Fabian، نويسنده , , Pavel and Hupp، نويسنده , , Ted R. and Vojtesek، نويسنده , , Borivoj، نويسنده ,
Issue Information :
روزنامه با شماره پیاپی سال 2013
Pages :
7
From page :
187
To page :
193
Abstract :
The pro-metastatic protein anterior gradient-2 (AGR2) was previously demonstrated as a predictive factor of poor response to tamoxifen treatment. In this study we aimed to delineate the key signalling pathway that may contribute to regulation of AGR2 protein induction in order to identify novel targets to overcome tamoxifen resistance in tumour cells. Together, our data identify PDPK1-AKT as a pro-oncogenic signalling pathway that triggers AGR2 protein induction in response to tamoxifen and suggest that AKT inhibitors could be used as part of a therapeutic strategy to treat tamoxifen resistant, AGR2 over-expressing cancers.
Keywords :
breast cancer , AGR2 , PDPK1 , Akt , Tamoxifen
Journal title :
Cancer Letters
Serial Year :
2013
Journal title :
Cancer Letters
Record number :
1822752
Link To Document :
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