Author/Authors :
Li، نويسنده , , Shibo and Zhang، نويسنده , , Lijun and Kern، نويسنده , , William F. and Andrade، نويسنده , , Dario and Forsberg، نويسنده , , Jean E. and Bates، نويسنده , , Francesca R. and Mulvihill، نويسنده , , John J.، نويسنده ,
Abstract :
A 32-year-old man was newly diagnosed with acute myelocytic leukemia, classified as acute myeloblastic leukemia with maturation (AML-M2) according to the French–American–British classification system. Conventional chromosome analysis before chemotherapy treatment revealed an abnormal karyotype: a possible segmental duplication of 11q23, plus a translocation between chromosomes 15 and 17 [t(15;17) (q22;q21.1)] in the majority of cells analyzed. Fluorescence in situ hybridization analysis using commercially available probes confirmed the cytogenetic findings. To our knowledge, this is the first report of a combination of t(15;17) and a segmental duplication of 11q23 in a patient with AML-M2.
