Title of article :
Synthesis and noncovalent DNA-binding properties of thiazole derivatives related to leinamycin
Author/Authors :
Leonid Breydo، نويسنده , , Leonid and Zang، نويسنده , , Hong and Gates، نويسنده , , Kent S.، نويسنده ,
Issue Information :
هفته نامه با شماره پیاپی سال 2004
Pages :
6
From page :
5711
To page :
5716
Abstract :
A series of compounds related to the macrocyclic portion of the DNA-damaging antitumor agent leinamycin were prepared as tools to characterize noncovalent DNA binding by this natural product. Acyclic (Z,E)-dienes were assembled via a Sonogashira coupling followed by partial hydrogenation. A Stille coupling was used in the cyclization step leading to a macrocyclic thiazole–diene analogue. Results obtained using the synthetic analogues reported here indicate that the extended π-system on the `left-hand sideʹ of leinamycin is required for noncovalent association of the natural product with duplex DNA.
Keywords :
DNA-binding , Nucleic acid chemistry
Journal title :
Tetrahedron Letters
Serial Year :
2004
Journal title :
Tetrahedron Letters
Record number :
1842595
Link To Document :
بازگشت