Author/Authors :
Zhao، نويسنده , , Zhengrong and Peacock، نويسنده , , Justin G. and Gubler، نويسنده , , Daniel A. and Peterson، نويسنده , , Matt A.، نويسنده ,
Abstract :
A series of 4,5-bis-(alkyn-1-yl)imidazoles—‘imidazole-fused’ enediynes—were synthesized and their reactivities in photoinduced Bergman cycloaromatization reactions were determined. The more conformationally rigid analogues gave cycloaromatized products in good yields upon irradiation (450 W low-pressure mercury lamp, ambient temperature). A bicyclic analogue (3) was shown to cleave supercoiled plasmid DNA.
