Author/Authors :
Xu، نويسنده , , Yanjie and Chen، نويسنده , , Ligong and Duan، نويسنده , , Xuemin and Meng، نويسنده , , Yi and Jiang، نويسنده , , Liqin and Li، نويسنده , , Meiling and Zhao، نويسنده , , Guangle and Li، نويسنده , , Yang، نويسنده ,
Abstract :
The total synthesis of hirsutellide A 1 was described. The linear hexadepsipeptide precursor 2 was synthesized in 45% yield from N-Boc-Me-Gly by three coupling reactions with DCC, HATU and BOP–Cl, respectively. Macrocyclization was successfully performed on the fully deprotected amino acid 14 with BOP–Cl in 15% yield and with FDDP in 22% yield.
Keywords :
Boc protection , Diazotization hydrolysis , Hirsutellide A , Coupled reagent , Cyclohexadepsipeptide
