Title of article :
Catalytic cyanosilylation of ketones using organic catalyst 1,1,3,3-tetramethylguanidine
Author/Authors :
Wang، نويسنده , , Lijia and Huang، نويسنده , , Xiao and Jiang، نويسنده , , Jun and Liu، نويسنده , , Xiaohua and Feng، نويسنده , , Xiaoming، نويسنده ,
Abstract :
1,1,3,3-Tetramethylguanidine acts as a highly effective catalyst for cyanosilylation of various ketones and aldehydes to the corresponding cyanohydrin trimethylsilyl ethers in up to 99% yield. The reaction proceeds smoothly with 0.1 mol % catalyst loading at 25 °C under solvent-free conditions.
