Author/Authors :
Li، نويسنده , , Limei and Li، نويسنده , , Guo-You and Xiao، نويسنده , , Wei-Lie and Zhou، نويسنده , , Yan and Li، نويسنده , , Sheng-Hong and Huang، نويسنده , , Sheng-Xiong and Han، نويسنده , , Quan-Bin and Ding، نويسنده , , Li-Sheng and Lou، نويسنده , , Liguang and Sun، نويسنده , , Han-Dong، نويسنده ,
Abstract :
Parvifoline X (1), a new rearranged ent-kaurane diterpenoid, and parvifoline Y (2), a new 8,15-seco-ent-kaurane diterpenoid, were isolated from the leaves of Isodon parvifolius. Their structures were elucidated by spectroscopic methods including 2D NMR analysis, and supported by a biogenetic pathway. Parvifoline X (1), possessing a new 15(8→11)-abeo-7α,20-epoxy-ent-kaurane skeleton, was found from the genus Isodon for the first time. Compounds 1 and 2 were evaluated for their inhibitory activity against A549, HT-29, and K562 cell lines. Parvifoline Y (2) was the most cytotoxic against A549 cells with an IC50 value of 4.97 μM.
Keywords :
NMR data , Parvifolines X and Y , Labiatae , Isodon parvifolius , cytotoxicity
